Ragni M V, Lewis J H, Spero J A, Bontempo F A, Rabin B S
Am J Med. 1984 Feb;76(2):206-10. doi: 10.1016/0002-9343(84)90775-7.
The immunologic status of three groups of multiply transfused asymptomatic patients was evaluated. These included five with acquired inhibitors to factor VIII treated with both factor VIII and factor IX concentrates (Group A), seven with hemophilia B treated with factor IX concentrate (Group B), and six with hemophilia B treated with fresh frozen plasma (Group C). Mean helper/suppressor T cell ratios (+/- SEM) for the three groups were 0.72 +/- 0.09, 1.35 +/- 0.18, and 1.37 +/- 0.12, respectively. All three differed significantly (p less than 0.01) from the control mean ratio of 2.22 +/- 0.16. In addition, the mean ratio of Group A patients was significantly different (p less than 0.01) from those of Groups B and C. An inverted ratio (less than 1.00) was found in all Group A patients and only one Group B patient. Increased IgG levels were found in 80, 57, and 50 percent of each group, respectively. These immunologic findings bear a striking resemblance to those of the acquired immunodeficiency syndrome (AIDS) of homosexuals, intravenous-drug abusers, Haitian immigrants, and factor VIII concentrate-treated hemophiliacs. Transmission via a blood-borne infectious agent seems likely.
对三组多次输血的无症状患者的免疫状态进行了评估。其中包括5例获得性Ⅷ因子抑制物患者，接受Ⅷ因子和Ⅸ因子浓缩物治疗（A组）；7例B型血友病患者，接受Ⅸ因子浓缩物治疗（B组）；以及6例B型血友病患者，接受新鲜冰冻血浆治疗（C组）。三组的辅助性T细胞/抑制性T细胞平均比值（±标准误）分别为0.72±0.09、1.35±0.18和1.37±0.12。这三组与对照组平均比值2.22±0.16均有显著差异（p<0.01）。此外，A组患者的平均比值与B组和C组有显著差异（p<0.01）。在所有A组患者及仅1例B组患者中发现比值倒置（<1.00）。三组中IgG水平升高的患者分别占80%、57%和50%。这些免疫学发现与同性恋者、静脉吸毒者、海地移民及接受Ⅷ因子浓缩物治疗的血友病患者的获得性免疫缺陷综合征（艾滋病）的表现极为相似。经血液传播感染因子传播似乎很有可能。
