Mannucci P M, Gringeri A, Ammassari M, Mari D
Am J Hematol. 1984 Aug;17(2):167-76. doi: 10.1002/ajh.2830170208.
Eighty-three symptom-free hemophiliacs were studied clinically, serologically and by in vitro tests for cellular immunity in a geographical area in which AIDS has not yet been encountered despite the exclusive use of concentrates manufactured from American sources of plasma. Some patients showed the following abnormalities: lymphopenia (4%), decreased T-helper/T-suppressor (Th/Ts) cell ratios (49%), or both abnormalities (2%). Low Th/Ts were mostly due to absolute or, less frequently, relative increases in Ts cells. The prevalence rates for these abnormalities were the same in patients treated with factor VIII or factor IX concentrates. There was an association between the higher Ts and lower Th cells counts and the low Th/Ts ratios and greater annual consumption of factor VIII and factor IX concentrates. These results support the view that protein load might be an important pathogenetic factor in lymphocyte abnormalities in symptom-free hemophiliacs.
在一个尚未发现艾滋病病例的地理区域，对83名无症状血友病患者进行了临床、血清学及细胞免疫体外测试研究，这些患者仅使用源自美国血浆的浓缩制剂。部分患者出现以下异常情况：淋巴细胞减少（4%）、辅助性T细胞/抑制性T细胞（Th/Ts）比值降低（49%），或两者皆有（2%）。Th/Ts比值降低主要是由于Ts细胞绝对数量增加，相对增加的情况较少。接受VIII因子或IX因子浓缩制剂治疗的患者中，这些异常情况的发生率相同。Ts细胞数量增多、Th细胞数量减少、Th/Ts比值降低与VIII因子和IX因子浓缩制剂的年使用量增加之间存在关联。这些结果支持以下观点：蛋白负荷可能是无症状血友病患者淋巴细胞异常的一个重要致病因素。
