Marchandise B, Bourassa M G, Chaitman B R, Lesperance J
Am J Cardiol. 1978 Feb;41(2):216-20. doi: 10.1016/0002-9149(78)90159-5.
Between September 1966 and September 1976, a group of 48 patients with normal coronary arteries or nonsignificant coronary atherosclerosis documented in a first coronary arteriogram underwent a second angiogram because of persistent or recurrent chest pain. The interval between studies was 13 to 108 months (mean 42 months). The indication for the first angiogram was typical or atypical anginal pain. The patients were separated into two groups according to the results of the first angiogram. Group I included 22 patients, 9 men and 13 women, with normal coronary arteries (mean age 49 years, range 28 to 62). Group II included 26 patients, 18 men and 8 women, with coronary stenosis of less than 50% of intraluminal diameter (mean age 49 years, range 38 to 63). The second angiogram revealed normal coronary arteries in all 22 patients in Group I but showed progression of diseases in 7 (27%) of the 26 patients in group II. The coronary arterial narrowings were greater than 50% in four patients and greater than 70% in only two patients. The clinical course, coronary risk factors and interval between angiograms were not useful predictors of progression of disease. The data suggest that coronary artery disease is unlikely to developed in adults with normal coronary arteries and that roughly 75% of adults with nonsignificant atherosclerosis will not show progression of disease over a 3 to 4 year period.
1966年9月至1976年9月期间，一组48例患者因持续性或复发性胸痛接受了第二次血管造影检查，这些患者在首次冠状动脉造影中显示冠状动脉正常或存在非显著性冠状动脉粥样硬化。两次检查之间的间隔时间为13至108个月（平均42个月）。首次血管造影的指征为典型或非典型心绞痛。根据首次血管造影的结果将患者分为两组。第一组包括22例患者，9名男性和13名女性，冠状动脉正常（平均年龄49岁，范围28至62岁）。第二组包括26例患者，18名男性和8名女性，冠状动脉狭窄小于管腔直径的50%（平均年龄49岁，范围38至63岁）。第二次血管造影显示，第一组的所有22例患者冠状动脉正常，但第二组的26例患者中有7例（27%）病情进展。4例患者的冠状动脉狭窄大于50%，仅2例患者的狭窄大于70%。临床病程、冠状动脉危险因素以及两次血管造影之间的间隔时间均不是疾病进展的有效预测指标。数据表明，冠状动脉正常的成年人不太可能患冠状动脉疾病，并且大约75%的非显著性动脉粥样硬化成年人在3至4年期间不会出现疾病进展。
