Prevention of induction of suppressor activity in human mononuclear leukocytes by ascorbate and cysteine in vitro.
作者信息
Eftychis H, Anderson R
出版信息
Int J Vitam Nutr Res. 1983;53(4):398-401.
PMID:6230331
Abstract
Concanavalin A (con A) and the non-steroidal anti-inflammatory drug benoxaprofen caused increased oxidative metabolism and suppressor activity in human mononuclear leukocytes in vitro. The relationship between enhanced oxidative metabolism and suppressor activity in MNL was investigated using the water-soluble anti-oxidants ascorbate and cysteine at fixed concentrations of 1 X 10(-3) M. Ascorbate and cysteine inhibited both the induction of suppressor activity and increased oxidative metabolism in MNL caused by con A and benoxaprofen. It is proposed that ascorbate and cysteine prevent the induction of non-specific suppressor activity in MNL by an anti-oxidant mechanism.
摘要
相似文献
1
Prevention of induction of suppressor activity in human mononuclear leukocytes by ascorbate and cysteine in vitro.
Int J Vitam Nutr Res. 1983;53(4):398-401.
2
Benoxaprofen activation of suppressor activity in mononuclear leucocytes by a pro-oxidative mechanism in vitro.
Agents Actions. 1984 Jun;14(5-6):649-53. doi: 10.1007/BF01978902.
3
Interaction of benoxaprofen with rat erythrocytes: effects on oxidative metabolism and membrane ATPase activities.苯恶洛芬与大鼠红细胞的相互作用：对氧化代谢和膜ATP酶活性的影响。
Res Commun Chem Pathol Pharmacol. 1986 Nov;54(2):227-36.
4
Inhibition of mitogen-activated proliferation of human lymphocytes by hypochlorous acid in vitro: protection and reversal by ascorbate and cysteine.体外次氯酸对人淋巴细胞有丝分裂原激活增殖的抑制作用：抗坏血酸和半胱氨酸的保护及逆转作用
Agents Actions. 1990 Jun;30(3-4):338-43. doi: 10.1007/BF01966297.
5
Mechanism of suppression of lymphocyte proliferation by Concanavalin A-activated mononuclear cells.伴刀豆球蛋白A激活的单核细胞抑制淋巴细胞增殖的机制。
Immunology. 1981 Jul;43(3):475-81.
6
7
8
9
10
Effects of non-steroidal anti-inflammatory drugs on human leucocytes.非甾体抗炎药对人体白细胞的影响。
Z Rheumatol. 1983 Jan-Feb;42(1):16-20.
Zotero 插件