苯恶洛芬与大鼠红细胞的相互作用：对氧化代谢和膜ATP酶活性的影响。
Interaction of benoxaprofen with rat erythrocytes: effects on oxidative metabolism and membrane ATPase activities.
作者信息
Knights K M, Cassidy M R, Ryall R G, Drew R
出版信息
Res Commun Chem Pathol Pharmacol. 1986 Nov;54(2):227-36.
Incubation of rat erythrocytes with benoxaprofen resulted in increased glucose utilization, lactate production, depletion of cellular ATP and significant haemolysis. In isolated red cell membranes, benoxaprofen produced a dose related stimulation of both Ca2+ dependent and Ca2+ independent ATPase activities. Coincubation of either erythrocytes or red cell membranes with cysteine ameliorated the effects of benoxaprofen. A possible association exists between the mechanism of the reported anti-inflammatory activity of benoxaprofen and its cellular toxicity.
将大鼠红细胞与苯恶洛芬一起孵育，会导致葡萄糖利用增加、乳酸生成、细胞ATP耗竭以及显著的溶血。在分离的红细胞膜中，苯恶洛芬对钙离子依赖型和非钙离子依赖型ATP酶活性均产生剂量相关的刺激作用。红细胞或红细胞膜与半胱氨酸共同孵育可改善苯恶洛芬的作用。苯恶洛芬所报道的抗炎活性机制与其细胞毒性之间可能存在关联。
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