Dirige O V, Jacob M, Ostergard N, Hunt I
Am J Clin Nutr. 1978 Feb;31(2):202-5. doi: 10.1093/ajcn/31.2.202.
The erythrocyte apoenzyme activities of transketolase, glutathione reductase, and glutamic-pyruvic transaminase were determined in 236 pregnant women during the first or second trimester and again during the third trimester. There were no differences in erythrocyte glutathione reductase and erythrocyte glutamic-pyruvic transaminase activities during these two periods. In contrast, erythrocyte transketolase decreased significantly in the third trimester. No statistically significant correlations were found between levels of activity for the various enzymes and dietary intakes of protein, vitamins or calories. The percent of subjects with low erythrocyte transketolase activity (a value one standard deviation or more below the mean initial value) increased significantly during the third trimester. The percent of subjects with low erythrocyte glutamic-pyruvic transaminase activity was significantly reduced during the third trimester although the mean apoenzyme level did not change. Vitamin deficiencies as measured by enzyme stimulation tests tended to occur less frequently among subjects with low enzyme activities but in no instance was there a statistically significant difference. Hence, no association could be found between apoenzyme activity and the incidence of vitamin deficiencies.
在236名孕妇的孕早期或孕中期以及孕晚期分别测定了转酮醇酶、谷胱甘肽还原酶和谷丙转氨酶的红细胞脱辅基酶活性。在这两个时期，红细胞谷胱甘肽还原酶和红细胞谷丙转氨酶活性没有差异。相比之下，红细胞转酮醇酶在孕晚期显著下降。各种酶的活性水平与蛋白质、维生素或热量的饮食摄入量之间未发现统计学上的显著相关性。红细胞转酮醇酶活性低（低于初始平均值一个标准差或更多）的受试者百分比在孕晚期显著增加。红细胞谷丙转氨酶活性低的受试者百分比在孕晚期显著降低，尽管脱辅基酶平均水平没有变化。通过酶刺激试验测定的维生素缺乏在酶活性低的受试者中发生频率较低，但在任何情况下都没有统计学上的显著差异。因此，在脱辅基酶活性与维生素缺乏发生率之间未发现关联。
