Schoen M S, Lindenbaum J, Roginsky M S, Holt P R
Am J Dig Dis. 1978 Feb;23(2):137-42. doi: 10.1007/BF01073189.
The serum 25-OHCC concentration was measured in 151 patients in order to evaluate the potential use of this determination in the management of gastrointestinal disorders. Patients with functional bowel disease had lower serum mean 25-OHCC levels than normals. The results were divided into normal (greater than 21 ng/ml), low normal (12-21 ng/ml), and low levels (less than 21 ng/ml). Two thirds of patients with malabsorption had low serum 25-OHCC. Most patients following jejunoileal bypass surgery for morbid obesity had low levels despite supplemental oral calciferol therapy. In patients with chronic liver disease, cholestasis more than parenchymal cell disease appeared responsible for low serum 25-OHCC levels. Measurement of serum 25-OHCC may be an ancillary screening test for fat malabsorption and in patients with intraluminal bile salt deficiency. Furthermore, repeated measurements may be useful in monitoring therapy with vitamin D products in patients with chronic malabsorption and cholestasis.
为评估血清25-羟胆钙化醇（25-OHCC）测定在胃肠道疾病管理中的潜在用途，对151例患者进行了该指标的检测。功能性肠病患者的血清平均25-OHCC水平低于正常人。结果分为正常（大于21 ng/ml）、低正常（12 - 21 ng/ml）和低水平（小于12 ng/ml）。三分之二的吸收不良患者血清25-OHCC水平较低。尽管接受了口服骨化醇补充治疗，但大多数因病态肥胖接受空肠回肠旁路手术的患者血清25-OHCC水平仍较低。在慢性肝病患者中，胆汁淤积比实质细胞疾病似乎更易导致血清25-OHCC水平降低。血清25-OHCC测定可能是脂肪吸收不良和肠腔内胆汁盐缺乏患者的一项辅助筛查试验。此外，重复检测可能有助于监测慢性吸收不良和胆汁淤积患者维生素D产品的治疗效果。
