Holst-Gemeiner D, Gemeiner M, Pilz I, Swoboda W
Wien Klin Wochenschr. 1978 Jul 14;90(14):509-12.
The effect of daily administration of 1200 IU vitamin D3 was compared with the response to a single oral dose of 200,000 IU in 21 young infants by determination of the plasma 25-OHCC levels. After about one week the mean value recorded in group 1 was 27 +/- 13 ng/ml; the corresponding value in group 2 was 127 +/- 78.4 ng/ml. At the second control examination about one month subsequently, the mean values were 61 +/- 26.2 ng/ml and 104 +/- 69.0 ng/ml respectively. The wide range of values found in the single-dose group clearly demonstrates the advantage of daily vitamin D administration for routine prophylaxis against rickets in infancy.
通过测定血浆25-羟胆钙化醇（25-OHCC）水平，比较了21名幼儿每日服用1200国际单位维生素D3与单次口服200,000国际单位的反应。大约一周后，第1组记录的平均值为27±13纳克/毫升；第2组的相应值为127±78.4纳克/毫升。在随后约一个月的第二次对照检查中，平均值分别为61±26.2纳克/毫升和104±69.0纳克/毫升。单剂量组中发现的数值范围很广，清楚地表明了每日服用维生素D在婴儿期常规预防佝偻病方面的优势。
