Schoeffler P, Haberer J P, Manhes H, Henry C, Habouzit J L
Ann Fr Anesth Reanim. 1984;3(1):10-5. doi: 10.1016/s0750-7658(84)80092-1.
Hemodynamic and respiratory variations were measured in ten obese women scheduled for laparoscopy. Peritoneal insufflation was associated with a decreased cardiac index (from 2.80 to 2.26 1 X min-1 X m-2; p less than 0.01) and increased systemic vascular resistances (from 1,230 to 1,940 dyn X s X cm-5). Heart rate remained stable (from 85 to 86 c X min-1). Mean arterial pressure was increased (from 86 to 104 mmHg; p less than 0.01). Placing the patients in Trendelenburg's position was associated with a small increase in cardiac index (from 2.26 to 2.49 l X min-1 X m-2; p less than 0.05). Under controlled ventilation, Paco2 was slightly increased (from 26 to 30 mmHg; p less than 0.01). A decrease in venous return due to intraperitoneal vascular compression explained the decrease in cardiac output. The rise in PaCO2 could be explained by CO2 reabsorption from the peritoneal cavity, and also by a change in the ventilation/perfusion ratio due to the curarization, mechanical ventilation and increased abdominal pressure. These results did not differ from the data available in non obese patients.
对十名计划接受腹腔镜检查的肥胖女性进行了血流动力学和呼吸变化的测量。气腹与心脏指数降低(从2.80降至2.26升/分钟×平方米;p<0.01)和全身血管阻力增加(从1230增至1940达因×秒×厘米⁻⁵)相关。心率保持稳定(从85次/分钟增至86次/分钟)。平均动脉压升高(从86毫米汞柱升至104毫米汞柱;p<0.01)。将患者置于头低脚高位与心脏指数小幅增加(从2.26升至2.49升/分钟×平方米;p<0.05)相关。在控制通气下,动脉血二氧化碳分压(Paco2)略有升高(从26毫米汞柱升至30毫米汞柱;p<0.01)。腹腔内血管受压导致静脉回流减少解释了心输出量的降低。动脉血二氧化碳分压(PaCO2)的升高可由腹膜腔二氧化碳重吸收以及由于箭毒化、机械通气和腹压增加导致的通气/灌注比变化来解释。这些结果与非肥胖患者的现有数据没有差异。