一种测量豚鼠重复性过敏反应的新的体内方法。
A new in vivo method for the measurement of repetitive anaphylactic responses in the guinea-pig.
作者信息
Bottomley K M, Lewis S, Rising T J, Steward A
出版信息
Br J Pharmacol. 1984 Jan;81(1):195-9. doi: 10.1111/j.1476-5381.1984.tb10761.x.
Abstract
The established Konzett-Rossler bronchorespiratory model has been combined with a unique ovalbumin sensitization procedure to give a novel method to measure anaphylaxis in the anaesthetized guinea-pig. Following antigen challenge, up to eight equal bronchoconstrictor responses to the same dose can be generated from a single animal over a 120 min period. Total inhibition of the anaphylactic response can be elicited by four different classes of compound, namely salbutamol, mepyramine, theophylline and dimaprit. Cromoglycate failed to cause any inhibition. The method is discussed with particular reference to the antigen sensitization procedure, which differs substantially from other regimens previously employed and gives rise to heat labile antibody.
摘要
已建立的孔泽特-罗斯勒支气管呼吸模型与独特的卵清蛋白致敏程序相结合，形成了一种在麻醉豚鼠中测量过敏反应的新方法。抗原激发后，在120分钟内，一只动物可对同一剂量产生多达八次相等的支气管收缩反应。四类不同的化合物，即沙丁胺醇、美吡拉敏、茶碱和地马普明，可引发过敏反应的完全抑制。色甘酸未能产生任何抑制作用。本文特别参照抗原致敏程序对该方法进行了讨论，该程序与先前采用的其他方案有很大不同，并产生热不稳定抗体。
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本文引用的文献
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Evaluation of pulmonary mechanics in guinea pigs during respiratory anaphylaxis.豚鼠在呼吸性过敏反应期间肺力学的评估。
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Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anaesthetized guinea-pigs.过敏介质抑制剂在麻醉豚鼠支气管过敏两种模型中的作用
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