Costabel U, Bross K J, Marxen J, Matthys H
Chest. 1984 Apr;85(4):514-22. doi: 10.1378/chest.85.4.514.
Recently, increased proportions of OKT 4+ helper T-lymphocytes have been reported in bronchoalveolar lavage (BAL) fluid of patients with active sarcoidosis. In this study we were interested in T-cell subsets of hypersensitivity pneumonitis, a disease characterized by a similar increase in BAL T-lymphocytes as active sarcoidosis. We applied an immunoperoxidase method performed on glass slides using the monoclonal antibodies OKT 3, 4, and 8 to study T-cell subsets in blood and BAL of eight patients with hypersensitivity pneumonitis, 11 patients with active sarcoidosis, and ten control subjects. OKT 8+ suppressor cells were found to be the predominant cell type in the BAL of patients with hypersensitivity pneumonitis and recent antigen exposure. After avoidance of further antigen exposure, suppressor cells decreased and helper cells increased. The results suggest that T-lymphocytosis in BAL of hypersensitivity pneumonitis and pulmonary sarcoidosis is mediated by different immunologic mechanisms.
最近，有报道称，在活动性结节病患者的支气管肺泡灌洗（BAL）液中，OKT 4+辅助性T淋巴细胞的比例有所增加。在本研究中，我们关注了过敏性肺炎的T细胞亚群，该疾病的特征是BAL T淋巴细胞的增加与活动性结节病相似。我们采用免疫过氧化物酶法，在载玻片上使用单克隆抗体OKT 3、4和8，研究了8例过敏性肺炎患者、11例活动性结节病患者和10名对照者血液和BAL中的T细胞亚群。发现OKT 8+抑制细胞是近期有抗原暴露的过敏性肺炎患者BAL中的主要细胞类型。在避免进一步抗原暴露后，抑制细胞减少，辅助细胞增加。结果表明，过敏性肺炎和肺结节病BAL中的T淋巴细胞增多是由不同的免疫机制介导的。
