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外螯菌素介导铁进入麻风分枝杆菌。

Exochelin-mediated iron uptake into Mycobacterium leprae.

作者信息

Hall R M, Wheeler P R, Ratledge C

出版信息

Int J Lepr Other Mycobact Dis. 1983 Dec;51(4):490-4.

PMID:6231257
Abstract

Iron chelated to the exochelins from Mycobacterium neoaurum was taken up by a suspension of M. leprae, prepared from the liver of an infected armadillo, over 15 hr. No uptake occurred when the iron was chelated with exochelins from M. bovis BCG or M. smegmatis or to a single exochelin from M. vaccae. Uptake appeared to be by facilitated diffusion since it was not inhibited by either HgCl2, NaN3, or 2,4-dinitrophenol. This was similar to the mode of uptake of ferriexochelin into M. neoaurum itself.

摘要

与新金色分枝杆菌外排铁载体螯合的铁,在15个多小时内被从感染犰狳肝脏制备的麻风分枝杆菌悬浮液摄取。当铁与卡介苗分枝杆菌或耻垢分枝杆菌的外排铁载体或与母牛分枝杆菌的单一外排铁载体螯合时,则不会发生摄取。摄取似乎是通过易化扩散进行的,因为它不受氯化汞、叠氮化钠或2,4-二硝基苯酚的抑制。这与铁外排铁载体进入新金色分枝杆菌自身的摄取模式相似。

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Leprosy.
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Clin Microbiol Rev. 1988 Jul;1(3):330-48. doi: 10.1128/CMR.1.3.330.