Vittoria A, Guerrini M, Pieragalli D, Del Bigo C, Martelli G, Franchi M, Messa G, Blardi P, Galigani C, Di Perri T
Ric Clin Lab. 1983;13 Suppl 3:315-21.
This study has been performed to evaluate the in vivo effect of acetylsalicylic acid (ASA) i.v. infusion at two different dosages: 500 and 2,000 mg on the main hemorheological parameters (blood viscosity and filtrability, hematocrit) and on beta-thromboglobulin (a platelet-specific protein) in patients with peripheral obliterative arterial disease, before and after an ischemic exercise. The results obtained before and 3 and 24 h after the drug administration induced us to think that platelet-specific substances released during the ischemic exercise can affect the hemorheological parameters and that ASA may be able to interfere with these reactions by inhibiting the platelet release.
本研究旨在评估静脉输注两种不同剂量（500毫克和2000毫克）乙酰水杨酸（ASA）对周围闭塞性动脉疾病患者在缺血运动前后主要血液流变学参数（血液粘度和过滤性、血细胞比容）以及β-血小板球蛋白（一种血小板特异性蛋白）的体内作用。给药前以及给药后3小时和24小时获得的结果使我们认为，缺血运动期间释放的血小板特异性物质可影响血液流变学参数，而ASA可能能够通过抑制血小板释放来干扰这些反应。
