Rund T E, Kierulf P, Godal H C, Aune S, Aasen A O
Adv Exp Med Biol. 1984;167:449-54. doi: 10.1007/978-1-4615-9355-3_39.
Changes in components of the plasma proteolytic enzyme systems were studied in nine patients with severe burns using chromogenic peptide substrate assay technique. All patients were critically ill and five died during a four week observation period. Plasma prekallikrein, plasminogen, prothrombin and platelet values decreases regularly in all patients after the injury. These changes were seen together with a high frequency of increases serum FDP values and presence of soluble fibrin. During critical illness extensive plasma proteolysis occurred, indicated by elevated plasma kallikrein and plasmin activities combined with lowered functional plasma kallikrein inhibition, prekallikrein and plasminogen values. The study confirms that plasma pathological proteolysis occurs in patients with severe burns, and indicates that close monitoring of components of the plasma proteolytic enzyme systems can give information of prognostic and therapeutic value in the severely burned patient.
采用发色肽底物测定技术，对9例重度烧伤患者血浆蛋白水解酶系统的成分变化进行了研究。所有患者病情都很严重，在为期四周的观察期内，有5例死亡。受伤后，所有患者的血浆前激肽释放酶、纤溶酶原、凝血酶原和血小板值均呈规律性下降。这些变化同时伴有血清FDP值升高和可溶性纤维蛋白的出现。在危重病期间，血浆激肽释放酶和纤溶酶活性升高，同时血浆激肽释放酶功能抑制、前激肽释放酶和纤溶酶原值降低，提示发生了广泛的血浆蛋白水解。该研究证实重度烧伤患者会发生血浆病理性蛋白水解，并表明密切监测血浆蛋白水解酶系统的成分可为重度烧伤患者提供具有预后和治疗价值的信息。
