用不同毒力水平的白色念珠菌菌株攻击对烧伤小鼠血浆蛋白的影响。
Effect of challenge with Candida albicans strains with different levels of virulence on plasma proteins in burned mice.
作者信息
Neely A N, Childress C M, Holder I A
机构信息
Shriners Burns Institute, Cincinnati, Ohio.
出版信息
Infect Immun. 1991 Apr;59(4):1576-8. doi: 10.1128/iai.59.4.1576-1578.1991.
Abstract
Immunoglobulin G, immunoglobulin A, transferrin, and fibrinogen were measured by radial immunodiffusion in plasma samples from burned versus unburned mice challenged with high-virulence Candida albicans MY 1044 or its low-virulence mutant, MY 1049. Early decreases in these proteins were found after burn and/or MY 1044 but not MY 1049 challenge. These decreases may contribute to increased susceptibility of mice that were burned and challenged by MY 1044 to lethal candidiasis.
摘要
通过放射免疫扩散法，对遭受高毒力白色念珠菌MY 1044或其低毒力突变体MY 1049攻击的烧伤小鼠和未烧伤小鼠的血浆样本中的免疫球蛋白G、免疫球蛋白A、转铁蛋白和纤维蛋白原进行了测定。在烧伤和/或遭受MY 1044攻击后，发现这些蛋白质早期减少，但遭受MY 1049攻击后未出现这种情况。这些减少可能导致遭受烧伤并受到MY 1044攻击的小鼠对致命性念珠菌病的易感性增加。
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