Schuyler M R, Gerblich A, Urda G
Arch Intern Med. 1984 May;144(5):973-5.
Alteration of T-cell subset relationships may cause many of the anti-inflammatory and immunoregulatory effects of glucocorticosteroids. The effect of oral administration of lactose or 60 mg of prednisone on peripheral blood T-lymphocyte subset profile and total eosinophil count (TEC) was examined. A purified T-cell peripheral blood population was obtained and the proportion of T cells with T3, T4, T8, M1, and la surface antigens was determined before and five hours after ingestion of lactose or prednisone. Lactose caused no change of any of the measured values. Prednisone caused a large (72%) decrease of the total lymphocyte number and the TEC (97%) but no change of the proportion of T cells with the previously mentioned antigens. Administration of 60 mg of prednisone does not acutely selectively deplete subclasses of T lymphocytes from peripheral blood.
T细胞亚群关系的改变可能导致糖皮质激素的许多抗炎和免疫调节作用。研究了口服乳糖或60毫克泼尼松对外周血T淋巴细胞亚群分布和嗜酸性粒细胞总数（TEC）的影响。获取纯化的T细胞外周血群体，并在摄入乳糖或泼尼松之前和之后5小时测定具有T3、T4、T8、M1和la表面抗原的T细胞比例。乳糖未引起任何测量值的变化。泼尼松使淋巴细胞总数大幅下降（72%），TEC下降（97%），但具有上述抗原的T细胞比例未发生变化。服用60毫克泼尼松不会急性选择性地从外周血中耗尽T淋巴细胞亚类。
