Gessman L, Reno C, Maranhao V
Cathet Cardiovasc Diagn. 1984;10(1):47-54. doi: 10.1002/ccd.1810100111.
We constructed a model of the human arterial circulation that can be used to test laser angioplasty catheters and techniques on obstructed human coronary arteries under simulated physiologic conditions of blood pressure and flow. In this model system, a balloon-tipped catheter with a central, 0.02-cm light fiber was used to deliver 4 W of laser energy to two obstructed human cadaver coronary artery segments and four normal dog femoral artery segments. Flushing the catheter with saline during the lases minimized lateral thermal tissue damage. Channels were created in the obstructed arteries that were twice the diameter of the light fiber used to lase. One of four dog arteries perforated, underscoring the potential hazards of the procedure and the need for laser catheters that are flexible and capable of precise alignment.
我们构建了一个人体动脉循环模型，可用于在模拟的血压和血流生理条件下，对阻塞的人体冠状动脉进行激光血管成形术导管和技术测试。在该模型系统中，使用带有中心0.02厘米光导纤维的球囊导管，将4瓦激光能量输送到两段阻塞的人体尸体冠状动脉节段和四段正常犬股动脉节段。激光照射期间用盐水冲洗导管可将侧向热组织损伤降至最低。在阻塞动脉中形成的通道直径是用于激光照射的光导纤维直径的两倍。四条犬动脉中有一条发生穿孔，突出了该操作的潜在风险以及对灵活且能精确对准的激光导管的需求。
