Schatten S, Granstein R D, Drebin J A, Greene M I
Crit Rev Immunol. 1984;4(4):335-79.
In this paper we have attempted to define the role of suppressor T cells in many well-defined murine tumor systems. We have knowingly omitted a blocking antibodies, suppressor B cells as mediators of tumor immunosuppression in various murine tumor systems; these have been well reviewed elsewhere. Also, we have focused on the importance of two different types of antigen-presenting cells in the induction and suppression of cell-mediated immunity and on some of the different modalities employed to inhibit Ts function. Finally, we have discussed the acquired immunodeficiency syndrome and the possible role of a defective helper pathway and enhanced suppressor pathway in its pathogenesis. We and others believe that the suppressor pathway is preferentially activated by tumor antigen(s) in the cases of many immunogenic murine tumors--possibly due to the release of tumor antigen(s) from tumor cells, their subsequent trafficking to specific areas of the spleen and other organs, and, ultimately, their presentation by certain APC to Ts. Ts may then act directly upon helper Lyt 1+2- T cells as these cells interact with tumor antigen(s) on I-A+ APC. Alternatively, if the effector pathway were somehow impaired--e.g., by ultraviolet radiation or a virus--then the suppressor pathway may be activated in an unregulated manner, often to the detriment of the host. Biochemical characterization of the tumor antigens that stimulate Ts generation and, presumably, tumor growth and definitive documentation of a role of APC in the processing and presentation of these tumor antigens to Ts need to be done. Then selective stimulation of the effector immune response, along with inhibition of the suppressor response, to tumor antigens with drugs, monoclonal antibodies, and soluble mediators or their analogues may be possible in the near future.
在本文中，我们试图确定抑制性T细胞在许多明确的小鼠肿瘤系统中的作用。我们有意忽略了阻断抗体、抑制性B细胞作为各种小鼠肿瘤系统中肿瘤免疫抑制介质的情况；这些内容在其他地方已有详尽综述。此外，我们着重探讨了两种不同类型的抗原呈递细胞在诱导和抑制细胞介导免疫中的重要性，以及一些用于抑制Ts功能的不同方式。最后，我们讨论了获得性免疫缺陷综合征以及缺陷辅助途径和增强的抑制途径在其发病机制中可能发挥的作用。我们和其他人认为，在许多免疫原性小鼠肿瘤的情况下，抑制途径优先被肿瘤抗原激活——这可能是由于肿瘤细胞释放肿瘤抗原，随后它们运输到脾脏和其他器官的特定区域，最终由某些抗原呈递细胞将其呈递给Ts。当这些细胞与I-A+抗原呈递细胞上的肿瘤抗原相互作用时，Ts可能直接作用于辅助性Lyt 1+2- T细胞。或者，如果效应途径以某种方式受损——例如，受到紫外线辐射或病毒影响——那么抑制途径可能会以不受调控的方式被激活，这通常会对宿主造成损害。需要对刺激Ts产生以及可能刺激肿瘤生长的肿瘤抗原进行生化特性分析，并确凿证明抗原呈递细胞在将这些肿瘤抗原加工和呈递给Ts过程中的作用。那么在不久的将来，使用药物、单克隆抗体、可溶性介质或其类似物选择性刺激针对肿瘤抗原的效应免疫反应并抑制抑制反应可能成为现实。
