来自荷瘤供体的被动转移抑制性T细胞对伴随抗肿瘤免疫产生的抑制作用。
Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors.
作者信息
Bursuker I, North R J
出版信息
Cancer Immunol Immunother. 1985;19(3):215-8. doi: 10.1007/BF00199229.
Abstract
Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.
摘要
给正常受体小鼠输注来自患有进行性Meth A纤维肉瘤供体的抑制性T细胞，会导致受体产生伴随性和切除后抗肿瘤免疫的能力下降。抑制性细胞的被动转移阻止了对Meth A纤维肉瘤免疫的产生，但不影响受体排斥同种异体肿瘤的能力。这些数据提供了直接证据，支持以下假设：在Meth A纤维肉瘤生长后期产生的抑制性T细胞，其功能是下调已经获得的伴随免疫机制。
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