来自荷瘤供体的被动转移抑制性T细胞对伴随抗肿瘤免疫产生的抑制作用。
Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors.
作者信息
Bursuker I, North R J
出版信息
Cancer Immunol Immunother. 1985;19(3):215-8. doi: 10.1007/BF00199229.
Abstract
Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.
摘要
给正常受体小鼠输注来自患有进行性Meth A纤维肉瘤供体的抑制性T细胞，会导致受体产生伴随性和切除后抗肿瘤免疫的能力下降。抑制性细胞的被动转移阻止了对Meth A纤维肉瘤免疫的产生，但不影响受体排斥同种异体肿瘤的能力。这些数据提供了直接证据，支持以下假设：在Meth A纤维肉瘤生长后期产生的抑制性T细胞，其功能是下调已经获得的伴随免疫机制。
相似文献
1
Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors.来自荷瘤供体的被动转移抑制性T细胞对伴随抗肿瘤免疫产生的抑制作用。
Cancer Immunol Immunother. 1985;19(3):215-8. doi: 10.1007/BF00199229.
2
Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity.对进行性纤维肉瘤免疫反应的产生与衰退。II. 在T细胞介导的免疫抑制开始后未能证明切除术后免疫。
J Exp Med. 1984 May 1;159(5):1312-21. doi: 10.1084/jem.159.5.1312.
3
Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.对进行性纤维肉瘤免疫反应的产生与衰退。I. Ly-1+2-抑制性T细胞下调Ly-1-2+效应性T细胞的产生。
J Exp Med. 1984 May 1;159(5):1295-311. doi: 10.1084/jem.159.5.1295.
4
Induction of antitumor immunity by tumor cells treated with abrin.
Cancer Res. 1982 Jul;42(7):2872-6.
5
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.环磷酰胺辅助的已建立肿瘤的过继性免疫疗法取决于肿瘤诱导的抑制性T细胞的清除。
J Exp Med. 1982 Apr 1;155(4):1063-74. doi: 10.1084/jem.155.4.1063.
6
Role of T suppressor cells in the cycling of the immune response against a murine fibrosarcoma.抑制性T细胞在针对小鼠纤维肉瘤的免疫反应循环中的作用。
Int J Cancer. 1984 Jul 15;34(1):95-100. doi: 10.1002/ijc.2910340117.
7
T cell suppressors of antitumor immunity. The production of Ly-1-,2+ suppressors of delayed sensitivity precedes the production of suppressors of protective immunity.抗肿瘤免疫的T细胞抑制因子。迟发型超敏反应的Ly-1-、2+抑制因子的产生先于保护性免疫抑制因子的产生。
J Exp Med. 1986 Oct 1;164(4):1179-92. doi: 10.1084/jem.164.4.1179.
8
Spontaneous tumor regression. Experimental aspects.自发性肿瘤消退。实验方面。
Urology. 1974 May;3(5):544-51. doi: 10.1016/s0090-4295(74)80244-x.
9
The stimulatory effect of tumor bearing upon the T- and B-cell subpopulations of the mouse spleen.荷瘤对小鼠脾脏T细胞和B细胞亚群的刺激作用。
Cancer Res. 1973 Oct;33(10):2247-56.
10
Ly-1+2- suppressor T cells inhibit the expression of passively transferred antitumor immunity by suppressing the generation of cytolytic T cells.Ly-1+2-抑制性T细胞通过抑制细胞毒性T细胞的产生来抑制被动转移的抗肿瘤免疫的表达。
Transplantation. 1985 Feb;39(2):202-8. doi: 10.1097/00007890-198502000-00018.
引用本文的文献
1
Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes.对头颈部癌肿瘤微环境进行开发和治疗性调控以改善临床结局。
Front Oral Health. 2022 Jul 22;3:902160. doi: 10.3389/froh.2022.902160. eCollection 2022.
2
Defining Immunogenic and Radioimmunogenic Tumors.定义免疫原性和放射免疫原性肿瘤。
Front Oncol. 2021 Mar 19;11:667075. doi: 10.3389/fonc.2021.667075. eCollection 2021.
3
Reciprocal changes in tumor antigenicity and antigen-specific T cell function during tumor progression.肿瘤进展过程中肿瘤抗原性与抗原特异性T细胞功能的相互变化。
J Exp Med. 2004 Dec 20;200(12):1581-92. doi: 10.1084/jem.20041240. Epub 2004 Dec 13.
4
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.调节性T细胞可阻止对低免疫原性黑色素瘤的伴随肿瘤免疫。
J Exp Med. 2004 Sep 20;200(6):771-82. doi: 10.1084/jem.20041130.
5
Antitumor effector mechanism at a distant site in the double grafted tumor system of PSK, a protein-bound polysaccharide preparation.蛋白结合多糖制剂PSK双移植瘤系统中远处位点的抗肿瘤效应机制
Jpn J Cancer Res. 1988 Aug;79(8):957-64. doi: 10.1111/j.1349-7006.1988.tb00061.x.
6
In vitro expression of secondary antitumor immunity by in vitro tumor-sensitized T cells: inhibition by tumor-induced suppressor T cells.体外肿瘤致敏T细胞的继发性抗肿瘤免疫体外表达：肿瘤诱导的抑制性T细胞的抑制作用
Cancer Immunol Immunother. 1987;25(2):69-74. doi: 10.1007/BF00199943.
7
Antitumor effect of PSK: role of regional lymph nodes and enhancement of concomitant and sinecomitant immunity in the mouse.PSK的抗肿瘤作用：区域淋巴结的作用以及对小鼠伴随免疫和伴随性免疫的增强
Jpn J Cancer Res. 1989 Feb;80(2):158-66. doi: 10.1111/j.1349-7006.1989.tb02284.x.
本文引用的文献
1
Immunity to methylcholanthrene-induced sarcomas.对甲基胆蒽诱导肉瘤的免疫性。
J Natl Cancer Inst. 1957 Jun;18(6):769-78.
2
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.环磷酰胺辅助的已建立肿瘤的过继性免疫疗法取决于肿瘤诱导的抑制性T细胞的清除。
J Exp Med. 1982 Apr 1;155(4):1063-74. doi: 10.1084/jem.155.4.1063.
3
T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases.T细胞介导的免疫抑制是P815肥大细胞瘤及其转移灶过继性免疫治疗的障碍。
J Exp Med. 1981 Oct 1;154(4):1033-42. doi: 10.1084/jem.154.4.1033.
4
T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.T细胞介导的抗肿瘤免疫抑制。免疫原性肿瘤进行性生长的一种解释。
J Exp Med. 1980 Jan 1;151(1):69-80. doi: 10.1084/jem.151.1.69.
5
Development of protective immunity against bacterial and viral infections in tumor-bearing mice coincident with suppression of tumor immunity.荷瘤小鼠中针对细菌和病毒感染的保护性免疫的发展与肿瘤免疫的抑制同时发生。
J Reticuloendothel Soc. 1982 Jul;32(1):25-35.
6
Specificity of the T cells that mediate and suppress adoptive immunotherapy of established tumors.介导和抑制已建立肿瘤的过继性免疫疗法的T细胞的特异性。
J Leukoc Biol. 1984 Jul;36(1):27-37. doi: 10.1002/jlb.36.1.27.
7
Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity.对进行性纤维肉瘤免疫反应的产生与衰退。II. 在T细胞介导的免疫抑制开始后未能证明切除术后免疫。
J Exp Med. 1984 May 1;159(5):1312-21. doi: 10.1084/jem.159.5.1312.
8
Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.对进行性纤维肉瘤免疫反应的产生与衰退。I. Ly-1+2-抑制性T细胞下调Ly-1-2+效应性T细胞的产生。
J Exp Med. 1984 May 1;159(5):1295-311. doi: 10.1084/jem.159.5.1295.
9
Suppressor T cells and the immune response to tumors.抑制性T细胞与肿瘤免疫反应
Crit Rev Immunol. 1984;4(4):335-79.
10
Gamma-irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells.γ射线照射通过消除抑制性T细胞来促进对已形成肿瘤的过继免疫的表达。
Cancer Immunol Immunother. 1984;16(3):175-81. doi: 10.1007/BF00205425.
Zotero 插件