Solomon L R, Rawlinson V I, Howarth S, Mallick N P
Nephron. 1984;37(1):54-9. doi: 10.1159/000183208.
IgG- and C3b-coated erythrocytes were used to investigate splenic Fc-receptor function and hepatic C3b-receptor function by measurements of their blood clearance. Most patients with glomerular disease including those who were HLA, A1, B8, DR3 had normal Fc-receptor function. Occasional individuals with persistent glomerulonephritis had delayed clearance unrelated to disease activity. In rapidly progressive glomerulonephritis, the phenomenon of 'reticulo-endothelial blockade' was confirmed. C3b-receptor function was normal in most patients with persistent glomerulonephritis. A defect in splenic Fc-receptor function hepatic C3b-receptor function is unlikely to underlie persistent glomerulonephritis.
使用 IgG 和 C3b 包被的红细胞，通过测量其血液清除率来研究脾脏 Fc 受体功能和肝脏 C3b 受体功能。大多数肾小球疾病患者，包括那些 HLA、A1、B8、DR3 阳性的患者，其 Fc 受体功能正常。偶尔有持续性肾小球肾炎患者的清除率延迟，与疾病活动无关。在快速进行性肾小球肾炎中，“网状内皮系统阻滞”现象得到证实。大多数持续性肾小球肾炎患者的 C3b 受体功能正常。脾脏 Fc 受体功能和肝脏 C3b 受体功能缺陷不太可能是持续性肾小球肾炎的基础。
