Willis L R, Bauer J H
Am J Physiol. 1978 Jan;234(1):F29-35. doi: 10.1152/ajprenal.1978.234.1.F29.
The effect of mineralocorticoid hormones on the urinary responses of spontaneously hypertensive and normotensive rats to oral salt loading was determined. In response to a control salt load, the increase was determined. In response to a control salt load, the increase in urinary sodium excretion by the spontaneously hypertensive rats was significantly greater than that of the normotensive rats [48 +/- 6 (SE) mueq/h vs. 26 +/- 4 mueq/h]. Treatment with spironolactone did not significantly alter the natriuretic response of the spontaneously hypertensive rats (43 +/- 8 mueq/h) to another salt load, but increased the natriuretic response of the normotensive rats (55 +/- 7 mueq/h) to that of the hypertensive rats. D-Aldosterone suppressed the natriuretic response to salt loading of the hypertensive rats to a level which was not significantly different from that of the normotensive rats. Plasma aldosterone concentration was significantly lower in the spontaneously hypertensive rats than in the normotensive rats (18.0 +/- 3.3 and 52.1 +/- 5.2 ng/100 ml, respectively). Neither extracellular fluid volume nor total body water in spontaneously hypertensive and normotensive rats were significantly different. The data support the hypothesis that the exaggerated natriuresis in the spontaneously hypertensive rats is mediated by a relative lack by these rats of aldosterone-mediated distal tubular sodium reabsorption.
研究了盐皮质激素对自发性高血压大鼠和正常血压大鼠口服盐负荷后尿液反应的影响。针对对照盐负荷，测定了（尿液变化）增加情况。对于对照盐负荷，自发性高血压大鼠尿钠排泄的增加显著大于正常血压大鼠[48±6（标准误）微当量/小时对26±4微当量/小时]。用螺内酯治疗并未显著改变自发性高血压大鼠（43±8微当量/小时）对另一次盐负荷的利钠反应，但增加了正常血压大鼠（55±7微当量/小时）的利钠反应，使其与高血压大鼠的反应相当。去氧皮质酮将高血压大鼠对盐负荷的利钠反应抑制到与正常血压大鼠无显著差异的水平。自发性高血压大鼠的血浆醛固酮浓度显著低于正常血压大鼠（分别为18.0±3.3和52.1±5.2纳克/100毫升）。自发性高血压大鼠和正常血压大鼠的细胞外液量及总体水量均无显著差异。这些数据支持以下假说：自发性高血压大鼠中过度的利钠作用是由这些大鼠相对缺乏醛固酮介导的远端肾小管钠重吸收所介导的。
