von Holst H, Granström E, Hammarström S, Samuelsson B, Steiner L
Acta Neurochir (Wien). 1982;62(3-4):177-85. doi: 10.1007/BF01403622.
The effects of leucotrienes C4 (LTC4), D4 (LTD4), Prostacyclin (PGI2) and Thromboxane A2 (TXA2) were studied on superfused human cerebral artery strips. LTC4 and LTD4 neither contracted nor relaxed the strips. PGI2 caused a dose-dependent relaxation from 0.2 nmol to 0.8 nmol. When given simultaneously with a vasoconstrictor substance, PGI2 had an almost complete inhibitory effect. TXA2 caused a dose-dependent contraction from 0.03 nmol to 0.15 nmol. Also, TXA2 was more potent than 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) with a contraction threshold of about 0.1 nmol. Prostaglandin E1 (PGE1), H2 (PGH2), and F2a (PGF2a) had contraction thresholds of about 1 nmol. Only a stable endoperoxide analogue (EPA), was more potent than TXA2, with a contraction threshold of 0.005 nmol. The possible role of these substances in producing ischaemic manifestations after subarachnoidal haemorrhage (SAH) is discussed.
研究了白三烯C4（LTC4）、白三烯D4（LTD4）、前列环素（PGI2）和血栓素A2（TXA2）对体外灌流的人脑动脉条的作用。LTC4和LTD4对动脉条既无收缩作用也无舒张作用。PGI2在0.2纳摩尔至0.8纳摩尔范围内引起剂量依赖性舒张。当与血管收缩物质同时给予时，PGI2几乎具有完全抑制作用。TXA2在0.03纳摩尔至0.15纳摩尔范围内引起剂量依赖性收缩。此外，TXA2比5-羟色胺（5-HT）和前列腺素E2（PGE2）更有效，收缩阈值约为0.1纳摩尔。前列腺素E1（PGE1）、前列腺素H2（PGH2）和前列腺素F2α（PGF2α）的收缩阈值约为1纳摩尔。只有一种稳定的内过氧化物类似物（EPA）比TXA2更有效，收缩阈值为0.005纳摩尔。讨论了这些物质在蛛网膜下腔出血（SAH）后产生缺血表现中可能的作用。
