清醒男性对等容性低氧的心率反应。

Heart rate response to isocapnic hypoxia in conscious man.

作者信息

Slutsky A S, Rebuck A S

出版信息

Am J Physiol. 1978 Feb;234(2):H129-32. doi: 10.1152/ajpheart.1978.234.2.H129.

DOI:10.1152/ajpheart.1978.234.2.H129

Abstract

We studied the effect of acute progressive hypoxia on heart rate in conscious healthy subjects. The PCO2 was held constant (+/- 1.5 mmHg) midway between the resting end-tidal and mixed-venous levels. Hypoxia was induced by having the subject rebreathe from a small bag so that the PO2 fell at a rate related to the subject's oxygen consumption. Arterial oxygen saturation (Sao2) was measured continuously during the procedure with an ear oximeter. We found that heart rate (HR) was best fitted to an inverse linear relation to arterial oxygen saturation and a power relation to PO2. The range of deltaHR/deltaSao2 was 0.62-1.46 beats/min per 1% fall in Sao2 (mean +/- SE = 0.98 +/- 0.06). There was no relationship between heart rate and ventilatory responses to hypoxia.

摘要

我们研究了急性进行性低氧对清醒健康受试者心率的影响。将二氧化碳分压维持在静息呼气末和混合静脉水平之间的中点（±1.5 mmHg）。通过让受试者从小袋子中进行重复呼吸来诱导低氧，以使氧分压以与受试者耗氧量相关的速率下降。在该过程中使用耳部血氧计连续测量动脉血氧饱和度（Sao2）。我们发现心率（HR）与动脉血氧饱和度呈最佳的反线性关系，与氧分压呈幂函数关系。Sao2每下降1%时，心率变化率（deltaHR/deltaSao2）的范围为0.62 - 1.46次/分钟（平均值±标准误 = 0.98 ± 0.06）。心率与对低氧的通气反应之间没有关系。