Tchórzewski H, Markiewicz K, Malec P
Immunol Lett. 1984;7(5):285-8. doi: 10.1016/0165-2478(84)90036-1.
Changes in the suppressor T-lymphocyte activity were studied in 11 patients with duodenal ulcer during treatment with cimetidine. The drug was administered intravenously in a dose of 200 mg four times a day for a fortnight. Suppressor T-cell activity was determined by the Shou et al. method using two-stage culture before treatment, after 4 days of the treatment, just before drug withdrawal, and 2 days and 2 wk after the treatment. Suppressor T-cell activity significantly decreased soon after starting the treatment, remained low throughout the treatment, and rapidly and significantly increased following drug withdrawal.
对11例十二指肠溃疡患者在使用西咪替丁治疗期间的抑制性T淋巴细胞活性变化进行了研究。药物以200毫克的剂量静脉注射，每日4次，持续两周。采用寿等人的方法，在治疗前、治疗4天后、停药前、治疗后2天和2周时，通过两阶段培养来测定抑制性T细胞活性。治疗开始后不久，抑制性T细胞活性显著下降，在整个治疗过程中保持较低水平，停药后迅速且显著升高。
