Yancey K B, Lawley T J
J Am Acad Dermatol. 1984 May;10(5 Pt 1):711-31. doi: 10.1016/s0190-9622(84)70087-9.
Circulating immune complexes (CICs) are a heterogeneous group of immunoreactants formed by the noncovalent union of antigen and antibody. Many factors influence the formation, immunochemistry, biology, and clearance of these soluble reactants. The recent development of sensitive assays for the detection of CICs and the capability to assess immune complex (IC) clearance mechanisms in humans in vivo have expanded our understanding of these mediators. CICs influence both the afferent and efferent limbs of the immune response and can mediate tissue damage in certain pathologic states. ICs probably play an important role in the pathogenesis of serum sickness, systemic lupus erythematosus, and cutaneous necrotizing vasculitis. Recent investigations have raised the possibility that CICs may be of significance in other types of vasculitis as well. In other instances, ICs may form in response to tissue injury and subsequently modify the immune response of the host. A review of this material with special emphasis on diseases of relevance to dermatologists is presented.
循环免疫复合物（CICs）是由抗原和抗体非共价结合形成的一组异质性免疫反应物。许多因素会影响这些可溶性反应物的形成、免疫化学、生物学特性及清除。用于检测CICs的灵敏检测方法的最新进展以及在人体内评估免疫复合物（IC）清除机制的能力，拓展了我们对这些介质的认识。CICs影响免疫应答的传入和传出环节，并且在某些病理状态下可介导组织损伤。ICs可能在血清病、系统性红斑狼疮和皮肤坏死性血管炎的发病机制中起重要作用。最近的研究提出了CICs在其他类型血管炎中也可能具有重要意义的可能性。在其他情况下，ICs可能因组织损伤而形成，随后改变宿主的免疫应答。本文将对该内容进行综述，特别强调与皮肤科医生相关的疾病。
