Yancey K B, Lawley T J
Am J Dermatopathol. 1983 Aug;5(4):401-5. doi: 10.1097/00000372-198308000-00013.
Immune complexes are products formed by the noncovalent union of antibody and antigen. Formation of immune complexes usually benefits the host by clearing antigens from the circulation. In some instances however, immune complexes are deposited in tissues with subsequent inflammation and tissue damage. The physiochemical characteristics of the immune complex, the status of the host's reticuloendothelial system, and the duration of exposure to antigen all influence the possibility of immune complex-mediated damage to tissues. Examples of this mechanism of injury are seen in serum sickness, systemic lupus erythematosus, and leukocytoclastic vasculitis. It is likely that the development of sensitive and reliable antigen-specific tests will provide more definitive information about the analysis of immune complex mediated injury.
免疫复合物是由抗体和抗原非共价结合形成的产物。免疫复合物的形成通常通过清除循环中的抗原而对宿主有益。然而，在某些情况下，免疫复合物会沉积在组织中，随后引发炎症和组织损伤。免疫复合物的理化特性、宿主网状内皮系统的状态以及抗原暴露的持续时间，都会影响免疫复合物介导的组织损伤的可能性。血清病、系统性红斑狼疮和白细胞破碎性血管炎中可见这种损伤机制的实例。灵敏可靠的抗原特异性检测方法的发展，可能会为免疫复合物介导的损伤分析提供更确切的信息。
