Nishikawa T, Strott C A
J Steroid Biochem. 1984 May;20(5):1123-7. doi: 10.1016/0022-4731(84)90354-6.
The outer (glomerulosa and fasciculata) and inner (reticularis) zones of the adrenal cortex of the guinea pig were separated and their steroid content determined. It was found that the concentration of 21-hydroxypregnenolone, deoxycorticosterone, corticosterone, aldosterone, 11-deoxycortisol, and cortisol was significantly higher in the outer cortical region, while the concentration of pregnenolone, 17-hydroxypregnenolone, and dehydroepiandrosterone was significantly higher in the inner zone. The concentration of progesterone, 17-hydroxyprogesterone, and androstenedione was not different in the two zones. Examination of specific steroid ratios suggested the following: (1) 3 beta-ol dehydrogenase/isomerase and 21-hydroxylase activities are reduced in the inner zone, (2) 17-hydroxylase and C17 20 lyase activities appear to be equally active in the two zones (3) 11 beta-hydroxylase activity appears to be more active in the inner zone (4) 21- hydroxypregnenolone , deoxycorticosterone, corticosterone, 11-deoxycortisol, and cortisol along with aldosterone are produced principally in the outer zone.
将豚鼠肾上腺皮质的外层（球状带和束状带）和内层（网状带）分离，并测定其类固醇含量。结果发现，21-羟孕烯醇酮、脱氧皮质酮、皮质酮、醛固酮、11-脱氧皮质醇和皮质醇的浓度在外层皮质区域显著更高，而孕烯醇酮、17-羟孕烯醇酮和脱氢表雄酮的浓度在内层区域显著更高。孕酮、17-羟孕酮和雄烯二酮的浓度在两个区域没有差异。对特定类固醇比例的检查表明如下：（1）3β-醇脱氢酶/异构酶和21-羟化酶活性在内层区域降低，（2）17-羟化酶和C17 20裂解酶活性在两个区域似乎同样活跃，（3）11β-羟化酶活性在内层区域似乎更活跃，（4）21-羟孕烯醇酮、脱氧皮质酮、皮质酮、11-脱氧皮质醇、皮质醇以及醛固酮主要在外层区域产生。
