Jones C A, Uhl C B, Mattox V R, Kinsey J H, Cortese D A, Lieber M M
J Surg Oncol. 1984 May;26(1):9-13. doi: 10.1002/jso.2930260104.
The photosensitizing/cytotoxic effects of four porphyrin compounds derived from hematoporphyrin were compared using two human tumor cell lines with a soft-agar colony-forming assay. Reproducible dose- and time-dependent increases in reproductive cell death were observed for each porphyrin tested. Two fractions derived from hematoporphyrin derivative (HPD) were found to be better photosensitizers than HPD itself, indicating the potential value of this in vitro assay for detecting the most active component from a heterogeneous mixture.
使用两种人类肿瘤细胞系，通过软琼脂集落形成试验比较了四种源自血卟啉的卟啉化合物的光敏/细胞毒性作用。对于每种测试的卟啉，均观察到生殖细胞死亡出现了可重复的剂量和时间依赖性增加。发现源自血卟啉衍生物（HPD）的两个组分比HPD本身具有更好的光敏剂作用，这表明该体外试验对于从异质混合物中检测最具活性的成分具有潜在价值。
