Schulman S, Lockner D
Thromb Res. 1984 May 1;34(3):213-6. doi: 10.1016/0049-3848(84)90004-5.
Fourteen patients with acute deep vein thrombosis (DVT) of the thigh were treated with different doses of streptokinase (SK) as a local venous infusion. Only the lowest SK-dose given, 4,000 U/h for 72 h, had any effect. Three out of 9 patients on this dose showed significant lysis. However, systemic hemorrhagic side effects occurred in 3 patients, local dermatitis in another 3. The reason for the limited thrombolytic effect and systemic side effects could be that the catheter is not in the immediate vicinity of the thrombus, and that the SK-infusion by-passes the occluded vein segments through collaterals. There is probably no advantage of local venous SK-infusion over systemic SK-therapy in DVT.
14例急性大腿深静脉血栓形成（DVT）患者接受了不同剂量链激酶（SK）的局部静脉输注治疗。仅给予的最低SK剂量，即4000U/h持续72小时，有任何效果。接受此剂量的9例患者中有3例显示出显著的溶栓效果。然而，3例患者出现全身性出血副作用，另外3例出现局部皮炎。溶栓效果有限和出现全身性副作用的原因可能是导管不在血栓紧邻部位，且SK输注通过侧支绕过了闭塞的静脉段。在DVT治疗中，局部静脉输注SK可能并不比全身性SK治疗有优势。
