Martin M, Heimig T, Fiebach B J, Riedel C
Geriatric Clinic, Städtische Kliniken, Duisburg, Germany.
Vasa. 1996;25(3):275-8.
The present study into the fibrinolytic therapy of deep vein thrombosis (DVT) considers whether streptokinase infusion into the dorsalis pedis vein of the affected leg (ipsipedal infusion) yields higher lysis rates than systemic infusion via the brachial vein (systemic infusion). In both cases the dosage regimen selected was a short-term ultra-high streptokinase (UHSK) infusion of 1.5 million IUSK/hour over a period of 6 hours (total SK dose: 9 million IU). A series of one to three UHSK infusions was given on one to three consecutive days. Forty patients were randomised to either systemic (Group S) or ipsipedal (Group IP) treatment. The distribution of important parameters determining a fibrinolytic response (e.g. the age, site and extent of DVT, and number of UHSK infusion series) was virtually identical in the two treatment groups. The rates for total and partial thrombolysis in the systemic infusion group were 50% and 10% respectively compared with 30% and 20% respectively in the ipsipedal group. The distribution of side-effects was approximately identical in the two groups. The results show that ipsipedal UHSK lysis via the dorsalis pedis vein confers no advantage over systemic infusion via the brachial vein.
本项关于深静脉血栓形成（DVT）纤维蛋白溶解疗法的研究探讨了向患侧腿部的足背静脉输注链激酶（同侧输注）是否比通过肱静脉进行全身输注（全身输注）产生更高的溶解率。在这两种情况下，所选的给药方案均为在6小时内以150万国际单位链激酶/小时的速度进行短期超高剂量链激酶（UHSK）输注（链激酶总剂量：900万国际单位）。连续1至3天进行一系列1至3次UHSK输注。40名患者被随机分为全身治疗组（S组）或同侧治疗组（IP组）。两个治疗组中决定纤维蛋白溶解反应的重要参数（如DVT的年龄、部位和范围以及UHSK输注系列的次数）分布基本相同。全身输注组的完全和部分溶栓率分别为50%和10%，而同侧组分别为30%和20%。两组的副作用分布大致相同。结果表明，通过足背静脉进行同侧UHSK溶解并不比通过肱静脉进行全身输注更具优势。
