佛波酯处理的3T3细胞中钙敏感、磷脂依赖性蛋白激酶活性的消失。
Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.
作者信息
Rodriguez-Pena A, Rozengurt E
出版信息
Biochem Biophys Res Commun. 1984 May 16;120(3):1053-9. doi: 10.1016/s0006-291x(84)80213-2.
PMID:6233972
Abstract
Treatment of intact 3T3 cells with biologically active phorbol esters causes a progressive decline in the total activity of Ca2+-sensitive, phospholipid-dependent protein kinase (protein kinase C) measured in cell-free, detergent-solubilized, extracts. The effect is dose-dependent and reversible; protein kinase C activity reappears when the phorbol esters are removed from the medium.
摘要
用生物活性佛波酯处理完整的3T3细胞，会导致在无细胞、去污剂溶解的提取物中测得的钙敏感、磷脂依赖性蛋白激酶（蛋白激酶C）的总活性逐渐下降。这种效应是剂量依赖性的且可逆；当从培养基中去除佛波酯时，蛋白激酶C活性会重新出现。
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