Shadab Md, Ali Nahid
Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India.
Mol Biol Int. 2011;2011:343961. doi: 10.4061/2011/343961. Epub 2011 Apr 27.
Protozoan parasites of the genus Leishmania are responsible for causing a variety of human diseases known as leishmaniasis, which range from self-healing skin lesions to severe infection of visceral organs that are often fatal if left untreated. Leishmania donovani (L. donovani), the causative agent of visceral leishmaniasis, exemplifys a devious organism that has developed the ability to invade and replicate within host macrophage. In fact, the parasite has evolved strategies to interfere with a broad range of signaling processes in macrophage that includes Protein Kinase C, the JAK2/STAT1 cascade, and the MAP Kinase pathway. This paper focuses on how L. donovani modulates these signaling pathways that favour its survival and persistence in host cells.
利什曼原虫属的原生动物寄生虫是导致多种被称为利什曼病的人类疾病的原因，这些疾病范围从可自愈的皮肤损伤到内脏器官的严重感染，如果不治疗往往会致命。内脏利什曼病的病原体杜氏利什曼原虫（L. donovani）是一种狡猾的生物体，它已发展出在宿主巨噬细胞内入侵和复制的能力。事实上，这种寄生虫已经进化出策略来干扰巨噬细胞中广泛的信号传导过程，包括蛋白激酶C、JAK2/STAT1级联反应和丝裂原活化蛋白激酶途径。本文重点关注杜氏利什曼原虫如何调节这些有利于其在宿主细胞中存活和持续存在的信号通路。
