六种缓释制剂口服给药后的茶碱生物利用度。
Theophylline bioavailability following oral administration of six sustained-release preparations.
作者信息
Spangler D L, Kalof D D, Bloom F L, Wittig H J
出版信息
Ann Allergy. 1978 Jan;40(1):6-11.
PMID:623398
Abstract
Plasma theophylline concentrations were measured in 20 adults after single doses of 8 mg/kg of each of six oral sustained-release theophylline preparations. Twelve subjects were studied in a multiple-dose trial. Comparison of bioavailability and absorption characteristics suggest usefulness of some of these products for the purpose of maintaining safe and effective blood levels with twice-a-day dosing.
摘要
对20名成年人单次服用六种口服缓释茶碱制剂中的每一种，剂量均为8mg/kg后，测定了血浆茶碱浓度。在一项多剂量试验中对12名受试者进行了研究。生物利用度和吸收特性的比较表明，其中一些产品对于通过每日两次给药维持安全有效的血药浓度是有用的。
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