急性链球菌感染后肾小球肾炎患者对A组链球菌抗原细胞反应性的抑制
Suppression of cellular reactivity to group A streptococcal antigens in patients with acute poststreptococcal glomerulonephritis.
作者信息
Reid H F, Read S E, Zabriskie J B, Ramkissoon R, Poon-King T
出版信息
J Infect Dis. 1984 Jun;149(6):841-50. doi: 10.1093/infdis/149.6.841.
Lymphocyte reactivity to group A streptococcal antigens was studied in patients with acute poststreptococcal glomerulonephritis (AGN) in Trinidad. When compared with controls, patients with AGN had significantly lower responses. This finding was most prominent in the patients who were greater than 10 years of age at onset of disease. The total number of T lymphocytes was found to be decreased in patients with AGN, and in particular, the percentage of cells bearing Fc receptors for IgG (T gamma) was low. Removal of the T gamma-cell population abrogated the lymphocyte response to streptococcal antigens. However, removal of the adherent cells resulted in enhancement of the response to the level of the normal control population. The presence of suppressor activity in the adherent cell population of older patients with AGN may be an important factor in progression of AGN to chronic disease.
在特立尼达，对患有急性链球菌感染后肾小球肾炎（AGN）的患者的淋巴细胞对A组链球菌抗原的反应性进行了研究。与对照组相比，AGN患者的反应明显较低。这一发现在疾病发作时年龄大于10岁的患者中最为突出。发现AGN患者的T淋巴细胞总数减少，尤其是携带IgG Fc受体的细胞（Tγ）百分比很低。去除Tγ细胞群体消除了淋巴细胞对链球菌抗原的反应。然而，去除贴壁细胞导致反应增强至正常对照群体的水平。年龄较大的AGN患者贴壁细胞群体中存在抑制活性可能是AGN进展为慢性疾病的一个重要因素。
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