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[在不同的¹⁴C和³H前体存在下标记利福霉素B的生物合成]

[Biosynthesis of the labelled rifamycin B in the presence of different 14C- and 3H-precursors].

作者信息

Subbotina N A, Beliavskaia I V, Griaznova N S, Teteriatnik A F, Sazykin Iu O

出版信息

Antibiotiki. 1978 Jan;23(1):31-4.

PMID:623446
Abstract

The results of studying the effectiveness of incorporation of the label from different 14C- and 3H-precursors into the molecule of rifamicin B during its biosynthesis are presented. The regularities of the label incorporation into the antibiotic composition as dependent on the time of the precursor addition were investigated. A radiochemically pure preparation of 14C-rifamicin B with specific radioactivity of 3 mcurie/mg was obtained.

摘要

本文展示了在利福霉素B生物合成过程中,研究不同14C和3H前体的标记掺入该分子有效性的结果。研究了标记掺入抗生素成分的规律与前体添加时间的关系。获得了比放射性为3毫居里/毫克的14C-利福霉素B放射化学纯制剂。

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