Faredin I, Tóth I
Acta Med Hung. 1984;41(1):19-34.
The in vitro metabolisms of [4-14C]-labelled DHA, delta 5-diol, delta 4-dione and Test were studied in skin tissue excised from the hairy hypogastric region of three patients diagnosed as suffering from "idiopathic hirsutism". The concentrations of DHA, And, delta 4-dione, delta 5-diol, Test, DHT, DHA-S, And-S, delta 5-diol-S and Test-S were determined in other portions of the same skin tissue. In the knowledge of the concentrations of the androgens and the C19-steroid sulphates in the blood and in the skin tissue, and also of the metabolisms of the main androgen precursors and Test in the hairy abdominal skin, new diagnoses can be established within the group of idiopathic hirsutisms : "pure peripheral hirsutism" and "mixed peripheral hirsutism". In the former the hyperactivity of the enzymes of the skin tissue takes part in the emergence of the disease form, while the latter involves the joint participation of the hyperactivity of the enzymes of the skin tissue and the high level of delta 4-dione in the blood. The picture of the metabolism in the hairy abdominal skin of the hirsute patients was dominated by Test formed in pathologically high amount from the precursors as a consequence of the hyperactivity of 17 beta-HSD. The formation of DHT and the activity of 5 alpha-R were of only secondary importance.
对三名被诊断为“特发性多毛症”患者的下腹部多毛区域切除的皮肤组织中[4-¹⁴C]标记的DHA、δ⁵-二醇、δ⁴-二酮和睾酮的体外代谢进行了研究。在同一皮肤组织的其他部分测定了DHA、雄烯二酮、δ⁴-二酮、δ⁵-二醇、睾酮、双氢睾酮、硫酸脱氢表雄酮、硫酸雄烯二酮、硫酸δ⁵-二醇和硫酸睾酮的浓度。了解血液和皮肤组织中雄激素和C19-类固醇硫酸盐的浓度，以及多毛腹部皮肤中主要雄激素前体和睾酮的代谢情况后，可在特发性多毛症组内建立新的诊断：“单纯外周性多毛症”和“混合外周性多毛症”。在前者中，皮肤组织酶的活性过高参与了疾病形式的出现，而后者则涉及皮肤组织酶活性过高和血液中δ⁴-二酮水平升高的共同作用。多毛症患者多毛腹部皮肤的代谢情况主要是由于17β-羟类固醇脱氢酶活性过高，以前体物质大量形成睾酮。双氢睾酮的形成和5α-还原酶的活性仅起次要作用。
