Goebel R, Leb G
Nuklearmedizin. 1976 Aug;15(4):201-3.
We compared an index for free thyroxine (FT4I) between groups of patients which were formed according to the results of radioiodine testing. An elevation of free thyroxine (as measured by the FT4I) which has been reported in elderly women by other authors could not be confirmed. Overlapping between euthyroidism and hyperthyroidism was not found as disturbing as reported elsewhere, a finding which can probably be explained by the different criteria for the categories "euthyroidism" and "hyperthyroidism". A group with depressed radioiodine uptake had an unexpected high percentage of elevated FT4I. These cases may be explained as toxic goitres. The incidence of hypothyroidism (as judged by FT4I) in this group is low compared with the incidence of obvious exogenous exposure to excessive iodide. Cases presenting with a normal radioiodide uptake together with absent suppression by thyroxine administration are more often connected with a normal FT4I and are therefore believed to be euthyroid; less frequently they are truly hyperthyroid (FT4I). In patients previously treated with radioiodine an elevated FT4I is found suprisingly often. A reevaluation of the radioiodine dosage and the course of the disease in these numerous patients seems to be indicated.
我们比较了根据放射性碘检测结果分组的患者群体之间的游离甲状腺素指数（FT4I）。其他作者报道的老年女性中游离甲状腺素升高（通过FT4I测量）情况未得到证实。未发现甲状腺功能正常与甲状腺功能亢进之间的重叠如其他地方报道的那样令人困扰，这一发现可能可以用“甲状腺功能正常”和“甲状腺功能亢进”类别的不同标准来解释。放射性碘摄取降低的一组患者中FT4I升高的比例意外地高。这些病例可能被解释为毒性甲状腺肿。与明显外源性过量摄入碘的发生率相比，该组中甲状腺功能减退（通过FT4I判断）的发生率较低。放射性碘摄取正常且给予甲状腺素后无抑制的病例更常与FT4I正常相关，因此被认为是甲状腺功能正常；它们真正甲状腺功能亢进（FT4I）的情况较少见。在先前接受过放射性碘治疗的患者中，FT4I升高的情况出乎意料地常见。似乎有必要对这些众多患者的放射性碘剂量和疾病进程进行重新评估。
