Kristoffersen Ulrik Sloth, Hesse Birger, Rasmussen Ase Krogh, Kjaer Andreas
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Clin Physiol Funct Imaging. 2006 May;26(3):167-70. doi: 10.1111/j.1475-097X.2006.00666.x.
To evaluate the importance of 24 h radioiodine uptake (24 h RIU) for the outcome of radioiodine treatment of hyperthyroidism.
Retrospective analysis of 72 patients who underwent radioiodine treatment for toxic goiter at our outpatient clinic [29 diffuse goiters (DG), 30 toxic multinodular goiters (TMG) and 13 toxic adenomas (TA)]. Thyroid status was determined by TSH, fT3 and fT4 levels, and outcome was rendered successful when hyperthyroidism was absent. Relation between low 24 h RIU (below median) or high 24 h RIU (above or equal to median) and outcome was evaluated.
Of patients with DG and low 24 h RIU, 15% remained hyperthyroid, as opposed to 56% of patients with DG and high 24 h RIU (P<0.05). Of patients with TMG and low 24 h RIU, none remained hyperthyroid, as opposed to 44% of patients with TMG and high 24 h RIU (P<0.01). Of patients with TA and low 24 h RIU, none remained hyperthyroid, as opposed to 43% of patients with TA and high 24 h RIU (NS, P = 0.19).
In patients with hyperthyroid disease treated with radioiodine the outcome is poorer for patients with high 24 h RIU compared with low 24 h RIU measured prior to treatment when the radioiodine dose is calculated on the basis of 24 h RIU.
评估24小时放射性碘摄取率（24 h RIU）对甲状腺功能亢进症放射性碘治疗结局的重要性。
回顾性分析在我院门诊接受毒性甲状腺肿放射性碘治疗的72例患者[29例弥漫性甲状腺肿（DG）、30例毒性多结节性甲状腺肿（TMG）和13例毒性腺瘤（TA）]。通过促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）水平确定甲状腺状态，若不存在甲状腺功能亢进，则治疗结局判定为成功。评估低24 h RIU（低于中位数）或高24 h RIU（高于或等于中位数）与治疗结局之间的关系。
DG且24 h RIU低的患者中，15%仍存在甲状腺功能亢进，而DG且24 h RIU高的患者中这一比例为56%（P<0.05）。TMG且24 h RIU低的患者中，无一人仍存在甲状腺功能亢进，而TMG且24 h RIU高的患者中这一比例为44%（P<0.01）。TA且24 h RIU低的患者中，无一人仍存在甲状腺功能亢进，而TA且24 h RIU高的患者中这一比例为43%（无统计学意义，P = 0.19）。
在接受放射性碘治疗的甲状腺功能亢进症患者中，当根据24 h RIU计算放射性碘剂量时，治疗前24 h RIU高的患者比24 h RIU低的患者结局更差。
