Mant T G, Tempowski J H, Volans G N, Talbot J C
Br Med J (Clin Res Ed). 1984 Jul 28;289(6439):217-9. doi: 10.1136/bmj.289.6439.217.
Since the introduction in 1979 of intravenous acetylcysteine (Parvolex) as an antidote for overdosage of paracetamol the National Poisons Information Service and the manufacturer have been notified of 38 adverse reactions that were anaphylactoid in nature and 19 accidental overdoses. The most common feature of the anaphylactoid reaction to normal dosage was rash; other features reported included angioedema, hypotension, and bronchospasm; all the patients recovered. The features associated with an overdose of acetylcysteine were similar but more severe; two patients died, but the extent to which the overdose of acetylcysteine may have been implicated was not clear in either case.
自1979年静脉注射乙酰半胱氨酸（Parvolex）作为对乙酰氨基酚过量中毒的解毒剂被引入以来，国家毒物信息服务中心和制造商已收到38例类过敏性质的不良反应报告以及19例意外过量用药报告。正常剂量下类过敏反应最常见的特征是皮疹；报告的其他特征包括血管性水肿、低血压和支气管痉挛；所有患者均康复。与乙酰半胱氨酸过量相关的特征相似但更严重；两名患者死亡，但在这两例中乙酰半胱氨酸过量所起的作用程度均不明确。
