Breen K J, Bury R W, Desmond P V, Forge B H, Mashford M L, Whelan G
Med J Aust. 1982 Jan 23;1(2):77-9. doi: 10.5694/j.1326-5377.1982.tb132164.x.
Over a four-year period, 103 patients presented to St Vincent's Hospital, Melbourne, after poisoning themselves with paracetamol. Most of them were young adults who suffered temporary emotional or social distress. There was severe liver damage in four patients who presented, or were recognised, 24 hours or more after the ingestion of paracetamol. The absence of severe liver damage in the remaining 99 patients was attributed to early intervention with specific therapy with orally administered methionine or intravenously administered N-acetylcysteine. We describe a rapid plasma paracetamol assay which can aid in the diagnosis and management of this problem. All physicians should be aware that paracetamol-induced hepatic necrosis is not clinically apparent for two to three days, and that it can be prevented by early specific treatment.
在四年时间里，103名患者在服用对乙酰氨基酚中毒后前往墨尔本的圣文森特医院就诊。他们大多数是遭受暂时情绪或社会困扰的年轻人。在摄入对乙酰氨基酚24小时或更长时间后就诊或被确诊的4名患者出现了严重肝损伤。其余99名患者未出现严重肝损伤归因于早期采用口服蛋氨酸或静脉注射N - 乙酰半胱氨酸进行特异性治疗。我们描述了一种快速血浆对乙酰氨基酚检测方法，它有助于诊断和处理这个问题。所有医生都应意识到，对乙酰氨基酚引起的肝坏死在两到三天内临床上并不明显，并且可以通过早期特异性治疗来预防。
