情感障碍和精神分裂症中的甲吡酮试验

The metyrapone test in affective disorders and schizophrenia.

作者信息

Fava G A, Carson S W, Perini G I, Morphy M A, Molnar G, Jusko W J

出版信息

J Affect Disord. 1984 Jun;6(3-4):241-7. doi: 10.1016/s0165-0327(84)80002-6.

Abstract

The metyrapone test was applied to patients suffering from major depressive illness with melancholia, from mania, and from schizophrenia. Hypoactivity of the HPA axis as assessed by the test appears to occur infrequently in affective disorders and schizophrenia. High normal or exaggerated responses to metyrapone, as observed in Cushing's disease, appear to be correlated to DST non-suppression in melancholia.

摘要

甲吡酮试验应用于患有伴有抑郁情绪的重度抑郁症、躁狂症和精神分裂症的患者。通过该试验评估的下丘脑-垂体-肾上腺（HPA）轴功能减退在情感障碍和精神分裂症中似乎很少发生。在库欣病中观察到的对甲吡酮的高正常或过度反应似乎与抑郁症中的地塞米松抑制试验（DST）不被抑制相关。