Morphy M A, Fava G A, Carson S W, Perini G I, Molnar G, Jusko W J
Neuropsychobiology. 1985;14(1):35-8. doi: 10.1159/000118198.
The metyrapone test, a useful and reliable procedure for assessing hypothalamic-pituitary-adrenocortical (HPA) axis function, was applied to schizophrenic patients and healthy controls. 4 out of 18 patients had subnormal responses to metyrapone whereas there were no such cases in the 22 control subjects. 1 schizophrenic patient and 3 control subjects had high normal responses to metyrapone. The relationship with the dexamethasone suppression test was found to be complex. These preliminary results suggest that the HPA axis activity patterns in psychiatric illness may be more complicated than previously reported.
甲吡酮试验是一种评估下丘脑 - 垂体 - 肾上腺皮质（HPA）轴功能的有用且可靠的方法，已应用于精神分裂症患者和健康对照者。18例患者中有4例对甲吡酮反应低于正常水平，而22名对照者中未出现此类情况。1例精神分裂症患者和3名对照者对甲吡酮反应处于正常高值。发现其与地塞米松抑制试验的关系较为复杂。这些初步结果表明，精神疾病中HPA轴的活动模式可能比之前报道的更为复杂。
