血卟啉衍生物及激光诱导光动力反应在肺癌治疗中的应用：21例初步报告

Application of hematoporphyrin derivative and laser-induced photodynamical reaction in the treatment of lung cancer: a preliminary report on 21 cases.

作者信息

Li J H, Chen Y P, Zhao S D, Zhang L T, Song S Z

出版信息

Lasers Surg Med. 1984;4(1):31-7. doi: 10.1002/lsm.1900040105.

DOI:10.1002/lsm.1900040105

Abstract

This paper reports results of hematoporphyrin derivative based on photodynamic therapy (PDT) of 24 lung cancer lesions in 21 patients that were followed at least three months. Three of 24 lesions exhibited complete remission and 20 of 24 lesions exhibited a response to PDT. Tumors in twenty of twenty-one patients exhibited visually discernible hematoporphyrin derivative fluorescence upon irradiation with the 514-nm line from an argon ion laser. There were no severe complications due to PDT. The hematoporphyrin derivative, argon iin laser pumped dye laser (rhodamine B) system,and quartz fiber we used in this clinical series were all made in the People's Republic of China.

摘要

本文报告了对21例患者的24处肺癌病灶采用基于血卟啉衍生物的光动力疗法（PDT）的结果，这些患者至少随访了三个月。24处病灶中有3处完全缓解，24处病灶中有20处对PDT有反应。21例患者中有20例的肿瘤在用氩离子激光的514纳米谱线照射时呈现出肉眼可见的血卟啉衍生物荧光。未出现因PDT导致的严重并发症。我们在这个临床系列中使用的血卟啉衍生物、氩离子激光泵浦染料激光（罗丹明B）系统和石英纤维均由中华人民共和国制造。