Nattie E E, Doble E A
Respir Physiol. 1984 May;56(2):253-9. doi: 10.1016/0034-5687(84)90109-9.
This study evaluated the threshold for intermittent hypoxia-induced right ventricular hypertrophy in the rat. Three groups of rats purchased from Hilltop Laboratory Animals, Inc., were exposed to air for 2 h, or an FIO2 = 0.1 for 1 h or 2 h daily for 28, 42 or 56 days. Packed cell volume (Hct) was significantly increased in both the 1 and 2 h hypoxic groups by 28 days. The ratios of (right ventricular wt)/(body wt) and the (right ventricular wt)/(left ventricular plus septum wt) significantly increased in the 2 h hypoxic group by 42 days. We conclude that 1 h of hypoxia per day for 28 days results in polycythemia and that 2 h of hypoxia per day for 42 days results in right ventricular hypertrophy in this rat strain.
本研究评估了间歇性低氧诱导大鼠右心室肥厚的阈值。从山顶实验动物公司购买的三组大鼠，分别每天暴露于空气中2小时，或每天暴露于FIO2 = 0.1的环境中1小时或2小时，持续28、42或56天。到28天时，1小时和2小时低氧组的红细胞压积（Hct）均显著升高。到42天时，2小时低氧组的（右心室重量）/（体重）和（右心室重量）/（左心室加室间隔重量）比值显著升高。我们得出结论，在该大鼠品系中，每天1小时低氧持续28天会导致红细胞增多症，每天2小时低氧持续42天会导致右心室肥厚。
