Kentera D, Susić D
Respiration. 1980;39(5):272-5. doi: 10.1159/000194227.
Normobaric hypoxia caused a significant increase in right/left ventricular weight ratio in rats, a reliable indicator of hypertrophy of the right ventricle, already after 1 week of intermittent hypoxic confinement 7 days after termination of a 4-week hypoxic exposure the right/left ventricular weight ratio was significantly lower compared to the values immediately after hypoxic treatment. 8 weeks of sojourning in a normoxic environment were not sufficient to normalize the right ventricular systolic pressure and right/left ventricular weight ratio. It is concluded that changes in the right ventricular mass in rat is a fast reaction to the changes in pressure load.
常压缺氧导致大鼠右心室/左心室重量比显著增加，这是右心室肥大的可靠指标，在间歇性低氧禁闭1周后就已出现。在4周低氧暴露终止7天后，右心室/左心室重量比与低氧治疗刚结束时相比显著降低。在常氧环境中停留8周不足以使右心室收缩压和右心室/左心室重量比恢复正常。得出的结论是，大鼠右心室质量的变化是对压力负荷变化的快速反应。
