Losa G A, Maestroni G J
Schweiz Med Wochenschr. 1984 Jun 23;114(25):930-2.
The effect of a bacterial extract orally administered to 20 children with recurrent infections of the upper respiratory tract was investigated in a double-blind study. The composition of the peripheral blood mononuclear cells (T and B lymphocytes, monocytes) and some of their biochemical properties (5'-nucleotidase, beta-N-acetyl-glucosaminidase and non-specific esterase) were unaffected. In contrast, the allogeneic mixed lymphocyte reaction was significantly increased in patients treated with the bacterial extract. In the treated group the number of infectious episodes decreased significantly and the clinical response correlated positively with the mixed lymphocyte reaction. These findings suggest that the bacterial extract has the capacity to restore depressed immune functions by acting through the gut-associated lymphoid tissue.
在一项双盲研究中，对20名患有上呼吸道反复感染的儿童口服一种细菌提取物的效果进行了调查。外周血单核细胞（T和B淋巴细胞、单核细胞）的组成及其一些生化特性（5'-核苷酸酶、β-N-乙酰氨基葡萄糖苷酶和非特异性酯酶）未受影响。相比之下，接受细菌提取物治疗的患者的同种异体混合淋巴细胞反应显著增强。在治疗组中，感染发作次数显著减少，临床反应与混合淋巴细胞反应呈正相关。这些发现表明，该细菌提取物有能力通过作用于肠道相关淋巴组织来恢复低下的免疫功能。
