Tyrer P, Treasaden I, Moreton K, Riley P, Flanagan R J, Dawling S
J Affect Disord. 1984 Aug;7(1):1-10. doi: 10.1016/0165-0327(84)90059-4.
The relationship between the dose and anxiolytic effects of diazepam and the serum concentrations of diazepam and nordiazepam were examined in groups of acutely and chronically anxious patients. The results showed a significant correlation between dose and serum nordiazepam concentrations after short-term (14-day) administration, but no significant association between clinical symptoms of anxiety and serum diazepam and nordiazepam. We conclude that the main value of serum benzodiazepine measurements in anxious patients in assessing compliance, particularly in patients suspected of taking more than the recommended dose. Serum nordiazepam is a more consistent index of dosage after chronic therapy than serum diazepam because it has a longer elimination half-time.
在急性和慢性焦虑症患者组中，研究了地西泮的剂量与抗焦虑作用以及地西泮和去甲地西泮的血清浓度之间的关系。结果显示，短期（14天）给药后，剂量与血清去甲地西泮浓度之间存在显著相关性，但焦虑的临床症状与血清地西泮和去甲地西泮之间无显著关联。我们得出结论，在评估焦虑症患者的依从性时，尤其是怀疑服用超过推荐剂量的患者，血清苯二氮䓬类药物测量的主要价值在于此。血清去甲地西泮在慢性治疗后比血清地西泮更能持续反映剂量情况，因为其消除半衰期更长。
