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脱髓鞘的遗传和分子方面

Genetic and molecular aspects of demyelination.

作者信息

Gonatas N K, Greene M I, Waksman B H

机构信息

Department of Pathology (Neuropathology), USA.

Department of Immunology, University of Pennyslvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Immunol Today. 1986 May;7(5):121-6. doi: 10.1016/0167-5699(86)90072-1.

DOI:10.1016/0167-5699(86)90072-1
PMID:25289996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7133909/
Abstract

Three groups of investigators came together to learn from each other in a workshop: neurologists and neuropathologists interested in the pathogenesis of multiple sclerosis (MS) and other demyelinative diseases of man and similar autoimmune and virus-induced model diseases in animals; immunologists and virologists concerned with the genetic controls found to play a role in these diseases; and geneticists and molecular biologists investigating specific gene products and their role in recognition function and cell interactions in model immunological systems.

摘要

三组研究人员齐聚一堂,在一个研讨会上相互学习:对多发性硬化症(MS)及人类其他脱髓鞘疾病的发病机制感兴趣的神经学家和神经病理学家,以及动物中类似的自身免疫和病毒诱导模型疾病的专家;关注在这些疾病中发现起作用的基因控制的免疫学家和病毒学家;还有研究特定基因产物及其在模型免疫系统中的识别功能和细胞相互作用中作用的遗传学家和分子生物学家。

相似文献

1
Genetic and molecular aspects of demyelination.脱髓鞘的遗传和分子方面
Immunol Today. 1986 May;7(5):121-6. doi: 10.1016/0167-5699(86)90072-1.
2
A search for virus in multiple sclerosis.多发性硬化症中病毒的探寻。
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Exp Neurol. 2007 Mar;204(1):88-94. doi: 10.1016/j.expneurol.2006.09.025. Epub 2006 Nov 28.
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Astrocytes: auxiliary cells for immune responses in the central nervous system?星形胶质细胞:中枢神经系统免疫反应的辅助细胞?
Immunol Today. 1990 Aug;11(8):265-8. doi: 10.1016/0167-5699(90)90106-j.
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Altered immune function in demyelinative disease.脱髓鞘疾病中免疫功能的改变。
Immunol Today. 1982 Dec;3(12):321-5. doi: 10.1016/0167-5699(82)90013-5.
6
Intra-axonal virus in demyelinative lesions of experimental herpes simplex type 2 infection.实验性2型单纯疱疹病毒感染脱髓鞘病变中的轴突内病毒
J Neurol Sci. 1984 Jan;63(1):63-74. doi: 10.1016/0022-510x(84)90109-6.
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The role of the Epstein-Barr virus receptor CD21 in multiple sclerosis.EB 病毒受体 CD21 在多发性硬化中的作用。
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[Childhood multiple sclerosis and allied demyelinative diseases].
No To Hattatsu. 1999 Jan;31(1):44-7.
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The role of costimulation in autoimmune demyelination.共刺激在自身免疫性脱髓鞘中的作用。
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Advances in Charcot-Marie-Tooth disease research: cellular function of CMT-related proteins, transgenic animal models, and pathomechanisms. The European CMT Consortium.夏科-马里-图思病研究进展:CMT相关蛋白的细胞功能、转基因动物模型及发病机制。欧洲CMT联盟。
Neurobiol Dis. 1997;4(3-4):215-20. doi: 10.1006/nbdi.1997.0148.

引用本文的文献

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Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis.从鼠实验性自身免疫性脑脊髓炎自然抗性研究中获得的经验教训。
Curr Trends Immunol. 2012;13:1-12.
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Experimental autoimmune encephalomyelitis in the mouse.小鼠实验性自身免疫性脑脊髓炎
Curr Protoc Immunol. 2007 May;Chapter 15:15.1.1-15.1.18. doi: 10.1002/0471142735.im1501s77.
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Vitamin D3 metabolism in patients with rheumatic diseases: low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus.风湿性疾病患者的维生素D3代谢:系统性红斑狼疮患者血清25-羟基维生素D3水平较低
Clin Rheumatol. 1995 Jul;14(4):397-400. doi: 10.1007/BF02207671.
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Frequency of blood-retina and blood-brain barrier changes in multiple sclerosis.多发性硬化症中血视网膜屏障和血脑屏障变化的频率
Ital J Neurol Sci. 1988 Aug;9(4):345-9. doi: 10.1007/BF02333997.
5
Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis.哺乳动物中枢神经系统移植的免疫学方面。综述与推测性综合分析。
Brain Res. 1988 Nov;472(3):287-324. doi: 10.1016/0165-0173(88)90010-0.

本文引用的文献

1
Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.实验性变应性脑脊髓炎:用一种识别辅助性T细胞的单克隆抗体在体内成功治疗
J Immunol. 1984 Oct;133(4):1938-42.
2
Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker.用针对T细胞亚群标志物的单克隆抗体逆转实验性变应性脑脊髓炎
Science. 1985 Jan 25;227(4685):415-7. doi: 10.1126/science.3155574.
3
Multiple sclerosis and human T-cell lymphotropic retroviruses.多发性硬化症与人类嗜T细胞逆转录病毒
Nature. 1985;318(6042):154-60. doi: 10.1038/318154a0.
4
Clinical viral infections and multiple sclerosis.临床病毒感染与多发性硬化症
Lancet. 1985 Jun 8;1(8441):1313-5. doi: 10.1016/s0140-6736(85)92801-6.
5
Chronic-relapsing experimental autoimmune encephalomyelitis. Myelin basic protein induces suppression of blastogenesis during remissions but not during exacerbations.慢性复发性实验性自身免疫性脑脊髓炎。髓鞘碱性蛋白在缓解期而非加重期诱导抑制母细胞形成。
J Neuroimmunol. 1985 Feb-Mar;7(5-6):345-53.
6
Slow virus infection: replication and mechanisms of persistence of visna virus in sheep.慢病毒感染:绵羊梅迪 - 维斯纳病毒的复制与持续存在机制
J Infect Dis. 1977 May;135(5):800-6. doi: 10.1093/infdis/135.5.800.