Tarleton R L, Kuhn R E
J Parasitol. 1984 Apr;70(2):253-60.
Previous work from this laboratory documented the presence of a suppressor substance in the serum of mice infected with Trypanosoma cruzi. Currently, however, we have been unable to demonstrate the presence of this suppressor factor, although infected mice were still profoundly suppressed in their ability to respond to SRBC, and suppressor cells were present in the spleens of these animals. Strains of T. cruzi other than the one presently in use in our laboratory gave similar results. Several possible explanations for our inability to demonstrate the presence of the suppressor factor in sera are discussed.
该实验室之前的研究记录了感染克氏锥虫的小鼠血清中存在一种抑制物质。然而，目前我们未能证实这种抑制因子的存在，尽管感染的小鼠对SRBC的反应能力仍受到严重抑制，且这些动物的脾脏中存在抑制细胞。我们实验室目前使用的克氏锥虫菌株以外的其他菌株也得出了类似结果。文中讨论了我们无法在血清中证实抑制因子存在的几种可能原因。
