Kato Y, Inouye T, Jyosui S, Kakimoto K, Iyehara-Ogawa H, Tsuruta S
Mutat Res. 1984 Aug;140(4):169-74. doi: 10.1016/0165-7992(84)90072-1.
A comparative survey of the mutagenic, prophage-inducing and antibacterial activities of 3 structure-related series of 5-nitro-furan derivatives including 5-nitro-2-furohydrazide imide, 5-nitro-2-furamide oxime and 5-nitro-2-furohydrazide has been undertaken. Among the compounds assayed, the 5-nitro-2-furohydrazide imide series was found to be most active with regard to mutagenic and antibacterial activities against Salmonella typhimurium TA100 and prophage-inducing activity in Escherichia coli GY5027. A clear correlation was observed between the chemical structure and the mutagenic and prophage-inducing activities which were approximately correlated to the antibacterial activity.
对3个结构相关系列的5-硝基呋喃衍生物（包括5-硝基-2-呋喃酰肼酰亚胺、5-硝基-2-呋喃酰胺肟和5-硝基-2-呋喃酰肼）的致突变、原噬菌体诱导和抗菌活性进行了比较研究。在所检测的化合物中，5-硝基-2-呋喃酰肼酰亚胺系列对鼠伤寒沙门氏菌TA100的致突变和抗菌活性以及对大肠杆菌GY5027的原噬菌体诱导活性表现出最强活性。观察到化学结构与致突变和原噬菌体诱导活性之间存在明显相关性，且这些活性与抗菌活性大致相关。
